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December 17, 2024

Gastric Fundus Ablation Explained

Revolutionizing Endoscopic Weight Loss Method

Obesity impacts millions of lives globally, increasing the risks of diabetes, cardiovascular diseases, and even certain cancers. While traditional weight-loss methods such as diets, exercise, and medications often result in limited success, a groundbreaking, minimally invasive procedure known as gastric fundus ablation is offering new hope for sustainable weight loss.

What is Gastric Fundus Ablation?

Gastric fundus ablation is an innovative endoscopic procedure that specifically targets the gastric fundus—the upper section of the stomach. This area plays a critical role in producing ghrelin, commonly known as the “hunger hormone.” By reducing ghrelin production and limiting stomach capacity, gastric fundus ablation curbs appetite and promotes earlier feelings of fullness, leading to sustainable and effective weight loss.

How Does Gastric Fundus Ablation Work?

This procedure utilizes targeted energy to alter the gastric fundus, achieving three key effects:

1. Reduced Ghrelin Production: Lower levels of ghrelin minimize hunger, reducing cravings and frequent snacking.

2. Smaller Stomach Capacity: Limiting the stomach’s ability to expand helps individuals feel full sooner during meals.

3. Slower Gastric Emptying: Food stays in the stomach for a longer period, prolonging the sensation of fullness.

Together, these effects create an effective weight-loss strategy without the need for more invasive surgical interventions.

Gastric fundus ablation

Benefits of Gastric Fundus Ablation

Gastric fundus ablation offers several advantages that make it an appealing alternative for individuals struggling with obesity:

Significant Weight Loss: Patients can expect to lose 10-25% of their initial body weight.

Improved Blood Sugar Control: Enhanced insulin sensitivity helps manage blood sugar levels, particularly for individuals with prediabetes or type 2 diabetes.

Reduced Hunger: Decreased ghrelin production translates to fewer hunger pangs and cravings.

Minimally Invasive: The endoscopic approach involves no incisions, resulting in lower risk and faster recovery.

Reversible: Unlike permanent surgical options, gastric fundus ablation can be adjusted or reversed if necessary.

Am I Eligible for Gastric Fundus Ablation?

Gastric fundus ablation may be an ideal solution if you meet the following criteria:

1. Obesity (BMI ≥30): With or without obesity-related comorbidities.

2. Failed Dietary Interventions: Prior attempts at diet and lifestyle changes have been unsuccessful.

3. Inadequate Response to Medications: Limited weight loss despite weight-loss medications.

4. High-Risk Surgical Candidate: For individuals who are not suitable for invasive bariatric surgeries like gastric bypass.

Note: A thorough medical evaluation will determine whether you are a suitable candidate for this procedure.

The Procedure: Step-by-Step

Gastric fundus ablation is a straightforward process typically completed in 30-60 minutes:

1. Preparation: Patients are required to fast before the procedure. Anesthesia is administered to ensure comfort.

2. Endoscope Insertion: A flexible endoscope is carefully inserted through the mouth into the stomach.

3. Fundus Identification: The gastric fundus is located and assessed.

4. Ablation: Targeted energy (radiofrequency, cryotherapy, or laser) is applied to modify the tissue in the fundus.

5. Post-Procedure Care: Patients are monitored for a short period and provided hydration and recovery guidance.

Recovery and Potential Side Effects

Gastric fundus ablation is associated with minimal downtime. Most patients recover within 1-3 days and can resume daily activities. Potential side effects include:

Mild Abdominal Pain: Temporary discomfort that typically resolves within a few days.

Nausea or Vomiting: Common but short-lived.

Bloating: Transient sensations of fullness or gas.

Dysphagia (Difficulty Swallowing): Rare and temporary in most cases.

Your doctor will provide specific post-procedure care instructions to ensure a smooth recovery.

How Does Gastric Fundus Ablation Compare to Other Weight-Loss Options?

Compared to other weight-loss interventions, gastric fundus ablation stands out:

Less Invasive: Unlike gastric bypass or sleeve gastrectomy, no surgical incisions are involved.

Lower Risk: The minimally invasive nature reduces the risk of complications associated with traditional bariatric surgeries.

Comparable Results: Weight loss is on par with other endoscopic options like endoscopic sleeve gastroplasty.

Gastric Fundus Mucosa Ablation (GFMA) Procedure: Before and After

Before the Procedure:

  1. Eligibility Assessment:
    • Patients typically undergo a thorough evaluation to determine their eligibility for GFMA. This includes a comprehensive medical history review, physical examination, and possibly psychological assessment to ensure they are suitable candidates for the procedure.
  2. Pre-Procedure Preparation:
    • Patients may be required to follow a specific diet or fasting protocol before the procedure to ensure the stomach is empty. This often involves avoiding solid foods for a certain period and consuming only clear liquids.
  3. Consultation and Education:
    • Patients receive detailed information about the procedure, its benefits, potential risks, and the lifestyle changes required post-procedure. This helps set realistic expectations and prepares them for the journey ahead.

The Procedure:

  • GFMA is performed endoscopically, meaning it is minimally invasive and does not require external incisions.
  • During the procedure, an endoscope is inserted through the mouth into the stomach. Energy is then applied to the mucosal layer of the gastric fundus to disrupt ghrelin production, the hormone responsible for stimulating appetite.
  • The procedure typically takes about 60 to 90 minutes and is performed under sedation or general anesthesia.

After the Procedure:

  1. Recovery:
    • Patients are usually monitored for a few hours post-procedure to ensure there are no immediate complications. Most can return home the same day.
    • Mild discomfort, nausea, or a sore throat may be experienced, but these symptoms generally resolve quickly.
  2. Dietary Guidelines:
    • Initially, patients are placed on a liquid diet, gradually progressing to soft foods and then to a regular diet over several weeks.
    • Long-term dietary changes are crucial for success, focusing on balanced, nutrient-rich meals and portion control.
  3. Follow-Up Care:
    • Regular follow-up appointments are essential to monitor weight loss progress, nutritional status, and overall health.
    • Patients may also receive support from dietitians or nutritionists to help maintain healthy eating habits.

Possible Complications

While GFMA is considered safe, like any medical procedure, it carries some risks. Possible complications include:

  • Bleeding: Minor bleeding may occur at the site of ablation.
  • Infection: Though rare, there is a risk of infection following the procedure.
  • Perforation: A very rare but serious complication where a hole forms in the stomach wall.
  • Gastrointestinal Symptoms: Temporary nausea, vomiting, or abdominal pain.

Eligibility for GFMA

GFMA is generally recommended for individuals who:

  • Have a body mass index (BMI) of 30 or higher, classifying them as obese.
  • Have not achieved significant weight loss through diet and exercise alone.
  • Are not suitable candidates for traditional bariatric surgery due to medical reasons or personal preference.
  • Are committed to making long-term lifestyle changes to support weight loss.

Success Rates

Studies have shown promising results for GFMA:

  • A study published in The Lancet Gastroenterology & Hepatology reported an average weight loss of 10-15% of total body weight within six months post-procedure.
  • Improvements in metabolic markers, such as insulin sensitivity and lipid profiles, have also been observed.
  • The procedure has a favorable safety profile, with minimal adverse effects reported.

In conclusion, GFMA offers a promising non-surgical option for weight loss, particularly for those who are not candidates for traditional bariatric surgery. With its focus on reducing appetite through hormonal modulation, it provides a unique approach to managing obesity. However, success largely depends on the patient's commitment to dietary changes and lifestyle modifications post-procedure.

Frequently Asked Questions

1. Is gastric fundus ablation suitable for everyone?

No. Certain conditions, such as severe gastroesophageal reflux disease (GERD), may contraindicate this procedure. Always consult your doctor.

2. How long does the procedure take?

The procedure typically lasts 30-60 minutes.

3. What is the recovery time?

Most patients recover fully within 1-3 days.

4. Can this procedure be combined with other weight-loss strategies?

Yes, but you should consult your healthcare provider to develop a comprehensive weight-loss plan tailored to your needs.

Dr Murat Ustun

About Dr Murat Ustun,

The Founder and Lead Bariatric Surgeon of IBC

Dr. Murat Ustun, a world-renowned Turkish/British bariatric surgeon, has long been at the forefront of innovative weight loss solutions. Known for his pioneering work in minimally invasive procedures, Dr. Ustun has made significant contributions to the field of bariatric surgery, particularly with the introduction and popularization of the Apollo Endoscopic Gastroplasty in Turkey. This procedure, which involves endoscopic suturing to reduce stomach size, has been a game-changer for patients seeking non-surgical weight loss options.

Building on his expertise and commitment to advancing bariatric care, Dr. Ustun has now begun offering Gastric Fundus Mucosa Ablation (GFMA) to his patients from around the globe. Recognizing the potential of GFMA as a revolutionary non-surgical method for weight loss, Dr. Ustun is leveraging his extensive experience to provide this cutting-edge treatment to those struggling with obesity.

Dr. Ustun's approach to GFMA is informed by his deep understanding of the physiological mechanisms underlying weight gain and appetite regulation. By targeting the gastric fundus to modulate ghrelin production, he aims to offer a safe and effective alternative to traditional bariatric surgeries. His dedication to patient care and innovation ensures that individuals seeking weight loss solutions receive the most advanced and personalized treatment available.

Patients from all over the world are now traveling to Turkey to benefit from Dr. Ustun's expertise in GFMA, drawn by his reputation for excellence and his track record of successful outcomes. As a leader in the field, Dr. Ustun continues to push the boundaries of what is possible in bariatric medicine, providing hope and transformative results for those in need.

Conclusion

Gastric fundus ablation represents an exciting advancement in obesity treatment. Its ability to target the hunger hormone and promote sustainable weight loss with minimal risk makes it a game-changing option for individuals seeking alternatives to traditional bariatric surgery.

If you are struggling with weight loss and considering this innovative procedure, consult a qualified healthcare professional to determine if gastric fundus ablation is right for you.

Additional Resources

For more information, visit the following trusted organizations:

American Society for Metabolic and Bariatric Surgery (ASMBS)

The Obesity Society (TOS)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Note: Always consult a licensed healthcare provider before pursuing any medical procedure. To discuss personal solutions for you please contact us.

This minimally invasive procedures could be the step you need to regain control over your weight and health. Stay informed, and take the first step toward a healthier you!

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